In this course we will focus on how active compounds are developed into a formulation suitable for dosing in animal studies and early human clinical trials. Factors such as the route of administration, enhancing the solubility of the drug substance, the crystalline form of the drug substance, drug substance vs. drug product, storage requirements, and how special requirements of the patient population play a role in the design of an ideal formulation will be covered. Finally, some of the differences encountered when formulating a biologic vs. a small molecule will be discussed.
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Pre-formulation
Ce cours fait partie de Spécialisation Drug Hunting: The Science of Making New Medicines
Enseigné en Anglais
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Instructeurs : Erland Stevens, PhD
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Détails à connaître
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mai 2024
11 quizzes, 3 devoirs
Cours
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Il y a 3 modules dans ce cours
Welcome, by the end of the course students will be able to: Define the concepts of formulation, drug substance, and drug product. Describe the role of pre-formulation in drug discovery and its impact on route of administration selection. List and explain the importance of physicochemical properties in drug discovery and development. Compare and contrast the pre-formulation considerations for small molecule drugs and biologics.
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