This course describes the basic nature if viruses and basic concepts of how they replicate. It looks at traditional methods for propagating and assaying viruses as well as methods to identify and follow them in individuals and populations. It will also look at how we can use molecular genetics to learn how viruses work in molecular detail.
What Are Viruses And How Do We Work With Them?
What Are Viruses And How Do We Work With Them?
Ce cours fait partie de Spécialisation Foundations in Virology and Vaccinology
Instructeur : Mike Skinner
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niveau Intermédiaire
Expérience recommandée
11 heures pour terminer
3 semaines à 3 heures par semaine
Planning flexible
Apprenez à votre propre rythme
Ce que vous apprendrez
Recognise how viruses cause infection
Recognise how vaccines prevent infections
Compétences que vous acquerrez
- Catégorie : Describe how we can detect, identify and track viruses in individuals and populations
- Catégorie : Identify the features of different vaccine platforms
- Catégorie : Recognise how transmission drives virus pathogenesis and shapes virus evolution
- Catégorie : Understand how the immune response mediates vaccine protection
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11 devoirs
Enseigné en Anglais
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Ce cours fait partie de la Spécialisation Foundations in Virology and Vaccinology
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Il y a 5 modules dans ce cours
The names of some viruses are instantly recognisable. The impact on an individual, a family, a community, and beyond, can be devastating. Disease, serious illness, and even death. Others have not been in the spotlight so much in recent years but have been incredible threats to humans and humanity. However, most recent COVID-19 pandemic, has shone a spotlight again on viruses and the fragility of our defences against, existing threats that are constantly mutating, adapting and evolving let alone against newly emerging threats. This week we look at the question: What are viruses?
Inclus
6 vidéos5 lectures2 devoirs
How do viruses replicate and spread? If we want to understand the fundamental characteristics of viruses, so that we can find ways to tackle them, we need to know how viruses replicate and spread. In this module, we are going to look at virus replication and spread and introduce some terms around these concepts.
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9 vidéos4 lectures2 devoirs
To be able to study viruses, we need to be able to isolate and then produce viruses using a process from horticulture called propagation. We can then use cells cultivated in mass quantities using laboratory techniques and pass the isolated virus cells through the cultivated cells to study the effects of the virus in a process called passaging. In this module, we will look at the development of propagation and passaging techniques – how these have evolved over time, and how they have impacted the development and production of vaccines.
Inclus
8 vidéos5 lectures3 devoirs
There was a lot in the media about variants and mutations during the COVID-19 pandemic. We had variants named after where they were first recognised. Then they were given Greek letter identifiers, such as delta and omicron. How important is it to have an understanding of how viruses evolve, and which types of viruses are likely to evolve much quicker than others? What is the impact of mutations on antiviral drug effectiveness? And overall, how are viruses, and the diseases they cause, shaped by mutation, selection and evolution? This week, we will look at virus mutation, their types and consequences, and the evolution of novel viruses through reassortment, recombination, and adaptation.
Inclus
5 vidéos2 lectures2 devoirs1 sujet de discussion
Conventional virus genetics talks about the range of genotypes, range of phenotypes, stability and quasispecies. Traditional genetic analysis often involves associating observable phenotypes with genotypes, then mapping the mutations causing those genotypes. Mapping normally involves looking at the genetic linkage between known and unknown genetic markers. In this module, we will look at viral genetics - the approaches used in conventional virus genetics, and the limitations of conventional virus genetics.
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6 vidéos3 lectures2 devoirs1 sujet de discussion
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The University of Hong Kong
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