Patient safety is of paramount importance for any drug discovery program. This course looks at some of the lessons learned which have influenced how promising molecules are currently evaluated for safety risks. In vitro and in vivo toxicology and safety studies are discussed, why they are performed, and how the data they provide guide a safety risk assessment, including determining a therapeutic index or safety window for a drug. Finally, the course will look at how safety data guide human dose selection, and some of the studies performed during clinical development.
Preclinical Safety
Preclinical Safety
This course is part of Drug Hunting: The Science of Making New Medicines Specialization
Instructors: Erland Stevens, PhD
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Gain insight into a topic and learn the fundamentals.
5.0
(17 reviews)
Intermediate level
Recommended experience
6 hours to complete
3 weeks at 2 hours a week
Flexible schedule
Learn at your own pace
Skills you'll gain
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Recently updated!
May 2024
Assessments
10 assignments
Taught in English
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This course is part of the Drug Hunting: The Science of Making New Medicines Specialization
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There are 3 modules in this course
Welcome, by the end of the course students will be able to: Recognize the role of toxicology in drug development and its differentiation from pharmacology. List and describe representative preclinical toxicology studies conducted to identify and quantify risks a small molecule may pose to a patient. Explain how preclinical safety assessments contribute to early human dose selection.
What's included
5 videos2 readings3 assignments
What's included
3 videos1 reading3 assignments
What's included
4 videos1 reading4 assignments
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