What Does MVP Stand For? It’s Not What You Think.
October 7, 2024
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This course is part of Drug Hunting: The Science of Making New Medicines Specialization
Instructors: Erland Stevens, PhD
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(42 reviews)
Recommended experience
Intermediate level
Advanced undergraduate coursework or practical familiarity/working knowledge in biological sciences and organic chemistry is recommended.
(42 reviews)
Recommended experience
Intermediate level
Advanced undergraduate coursework or practical familiarity/working knowledge in biological sciences and organic chemistry is recommended.
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This course begins with a review of routes of administration, ADME (absorption, distribution, metabolism, & excretion), and the use of in vivo drug concentration-time data to determine key pharmacokinetic parameters, like volume of distribution, half-life and clearance. The course then emphasizes in vitro assays that allow rapid prediction of ADME and PK properties for evaluation of new compounds. The later stages of the course focus on how drug discovery teams study this PK/PD relationship, as well as dose size and frequency predictions which ultimately assist in selection of a compound for advancement into the clinic.
This course is suitable for life scientists, clinicians, and individuals from fields that support drug discovery (e.g., patents, finance, licensing, etc.) interested in learning more about the pharmaceutical/biotechnology sector. Advanced undergraduate coursework or practical familiarity/working knowledge in biological sciences and organic chemistry is recommended.
Welcome, by the end of the course students will be able to: Summarize the key concepts of pharmacokinetics (PK), ADME (Absorption, Distribution, Metabolism, and Excretion), volume of distribution, half-life and clearance. Differentiate between different routes of drug administration and their impact on PK parameters. Define and describe the influence of transporters, plasma protein binding (PPB) and drug-drug interactions (DDIs) on the PK of a drug molecule. Explain how PK/PD relationships are derived and their importance for defining the anticipated human dose.
5 videos1 reading4 assignments
5 videos1 reading6 assignments
5 videos1 reading5 assignments
We asked all learners to give feedback on our instructors based on the quality of their teaching style.
Instructor ratings
We asked all learners to give feedback on our instructors based on the quality of their teaching style.
Peking University
Course
University of Colorado System
Course
University of Minnesota
Specialization
University of Colorado Boulder
Course
42 reviews
90.47%
9.52%
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Reviewed on Jul 14, 2024
Amazing to-the-point course content, great citations to key articles and questions which are very helpful for permenance. I'm pleased as a medical doctor in drug research. Thanks for this course!
Reviewed on Sep 7, 2024
Amazing course for people intending to pursue higher studies in the field of pharmacology
Reviewed on Nov 3, 2024
very good guide entire course gives great insight on industry
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