In this course we will focus on how active compounds are developed into a formulation suitable for dosing in animal studies and early human clinical trials. Factors such as the route of administration, enhancing the solubility of the drug substance, the crystalline form of the drug substance, drug substance vs. drug product, storage requirements, and how special requirements of the patient population play a role in the design of an ideal formulation will be covered. Finally, some of the differences encountered when formulating a biologic vs. a small molecule will be discussed.
Pre-formulation
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Pre-formulation
This course is part of Drug Hunting: The Science of Making New Medicines Specialization
Instructors: Erland Stevens, PhD
Included with 
Gain insight into a topic and learn the fundamentals.
4.7
(18 reviews)
Intermediate level
Recommended experience
8 hours to complete
3 weeks at 2 hours a week
Flexible schedule
Learn at your own pace
Details to know
Shareable certificate
Add to your LinkedIn profile
Assessments
14 assignments
Taught in English
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This course is part of the Drug Hunting: The Science of Making New Medicines Specialization
When you enroll in this course, you'll also be enrolled in this Specialization.
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There are 3 modules in this course
Welcome, by the end of the course students will be able to: Define the concepts of formulation, drug substance, and drug product. Describe the role of pre-formulation in drug discovery and its impact on route of administration selection. List and explain the importance of physicochemical properties in drug discovery and development. Compare and contrast the pre-formulation considerations for small molecule drugs and biologics.
What's included
4 videos1 reading3 assignments
What's included
5 videos6 assignments
What's included
5 videos5 assignments
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