This course familiarizes students with the novel concepts being used to revamp regulatory toxicology in response to a breakthrough National Research Council Report “Toxicity Testing in the 21st Century: A Vision and a Strategy.” We present the latest developments in the field of toxicology—the shift from animal testing toward human relevant, high content, high-throughput integrative testing strategies. Active programs from EPA, NIH, and the global scientific community illustrate the dynamics of safety sciences.
Toxicology 21: Scientific Applications
Toxicology 21: Scientific Applications
Instructors: Lena Smirnova
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Gain insight into a topic and learn the fundamentals.
4.6
(82 reviews)
Intermediate level
Some related experience required
Flexible schedule
Approx. 167 hours
Learn at your own pace
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9 assignments
Taught in English
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There are 7 modules in this course
This model will give you a broad introduction to the Toxicology 21st century (Tox21c) field and familiarize you with the main document, which summarize the main ideas and principles of Tox21c.
What's included
10 videos3 readings1 assignment1 discussion prompt
This module will discuss how ToxCast and Tox21 technologies can be used in practice. The US EPA Endocrine Disruptor Screening Program will be discussed in detail and we will demonstrate how the ToxCast platform replaced in vivo tiered approaches in EDSP and, thus, acelerate the process of . In the second lesson of this module, the development of in silico models for toxicity testing will be discussed.
What's included
10 videos4 readings1 assignment1 peer review2 discussion prompts
This module will familiarize you with the Human Toxome Project run by Johns Hopkins University in collaboration with several university, industry, and research agencies. Omics technologies, their advantages and disadvantages, as well as concepts of Adverse Outcome Pathways (AOP) and Pathways of Toxicity (PoT) will be discussed.
What's included
10 videos2 readings1 assignment1 discussion prompt
The first lesson in this module will explain the concept of read-across, why it is important for regulatory risk assessment, and how it can be implemented by industry in response to REACH legislation. The organotypic cultures lesson will teach you about existing in vitro cell-based models starting from simple monolayer cultures of cell lines and ending with complex combined organ-on-a-chip and human-on-a-chip approaches.
What's included
18 videos3 readings2 assignments1 discussion prompt
This module will teach you the role of miRNA and epigenetics in toxicology and environmental health.
What's included
6 videos1 reading1 assignment1 discussion prompt
In this module you will learn about important component of in vitro toxicology such as in vitro to in vivo extrapolation (IVIVE) and physiologically based biokinetic modeling. You will learn why it is important to consider biokinetics in vitro and see some example of biokinetics modeling in vitro. This lesson will also give you a biometry prospective of in vitro toxicology. You will learn which methods can be used to analyze big data.
What's included
8 videos3 readings1 assignment1 peer review
In this lesson you will learn about integrated testing strategies and how they differ from individual tests or test batteries. Also a wrap-up lesson "beyond chemical" will summaries your knowledge from this course and give a out-look for further directions in the field of alternatives to animal testing.
What's included
11 videos2 readings2 assignments
Instructors
Instructor ratings
4.7 (30 ratings)Offered by
Recommended if you're interested in Basic Science
Johns Hopkins University
Novartis
Google Cloud
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